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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227665Generated: October 30, 2026

Benzoyl chloride → ethyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

https://huagongshe.com/reaction/2227665

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzoyl chlorideHCID 7412—
Reactant1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochlorideHCID 18412298—
Productethyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoateHCID 140435599—

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and benzoyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06414008B1
Source datasetuspto-grants-2002_07
ORD IDord-7548bdab721343c9a1687736d2fd2b23
Source noteuspto-grants-2002_07