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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227673Generated: October 29, 2026

Sodium Hydroxide → 1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amide

https://huagongshe.com/reaction/2227673

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide HydrochlorideHCID 18412529—
Product1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amideHCID 18412398—

Reaction Steps

Prepared analogously to Example 26 from 1-cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06414008B1
Source datasetuspto-grants-2002_07
ORD IDord-dac76d82d7604bd8a442e90989e90614
Source noteuspto-grants-2002_07