Hydrogen Peroxide → HCID 12043647, compound

Participants

Reaction Steps

Reaction of 3-dimethylamino-1-[4-(4-fluorophenoxy)phenyl]-propenone with 2-cyanoethylhydrazine as described above gave 1-(2-cyanoethyl)-5-[4-(4-fluorophenoxy)phenyl]pyrazole. Reaction of a solution of the nitrile with 10 mL of a 20% aqueous KOH solution and 4 mL of an aqueous 30% H2O2 solution at reflux gave 64 mg of the amide as a white solid, mp 118-120° C. 1H NMR (CDCl3): δ7.54 (d, 1H, J=1.8 Hz), 7.35 (d, 2H, J=8.7 Hz), 7.10-6.98 (m, 6H), 6.26 (d, 1H, J=1.8 Hz), 6.08 (br s, H), 5.30 (br s, 1H), 4.39 (t, 2H, J=6.6 Hz), 2.86 (t, 3H, J=6.6 Hz).

Provenance & Evidence