2-Methoxyethanol → HCID 136023931, compound

HRID 2227787Notes

Reaction equation

HRID 2227787 reaction equation
Br[C:2]1[NH:3][C:4](=[O:11])[C:5]2[NH:6][CH:7]=[N:8][C:9]=2[N:10]=1.[CH2:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][N:16]=1)[CH3:13].COCCO>O>[CH2:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:2]2[NH:3][C:4](=[O:11])[C:5]3[NH:6][CH:7]=[N:8][C:9]=3[N:10]=2)=[CH:17][N:16]=1)[CH3:13]

Participants

5

Reactant 3

HCID 80192-MethoxyethanolHCID 30403016-Ethoxypyridin-3-amineHCID 1354139912-Bromohypoxanthine

Product 1

HCID 136023931HCID 136023931, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-bromohypoxanthine (6.3 g; 29.3 mmol), 2-ethoxy-5-aminopyridine (12.1 g; 87.9 mmol), 2-methoxyethanol (90 mL), and water (15 mL) is heated under reflux for 3 h. The reaction mixture is cooled to room temperature, the precipitate collected by filtration and washed with water and methanol to afford N2-(2-Ethoxypyridin-5-yl)guanine (6.4 g), m.p. >350° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 3 h
  3. filtrationthe precipitate collected by filtration
  4. washwashed with water and methanol

Sources & evidence

ORD record
ord-54bb012e8d664307b6b64a9976cb5704
Source dataset
uspto-grants-2002_07
Patent number
US06414147B1

Reaction notes

Loading…