N-bromobutanimide → 407636-44-6

HRID 2227855Notes

Reaction equation

HRID 2227855 reaction equation
C1C(=O)N([Br:8])C(=O)C1.[CH3:9][O:10][C:11](=[O:20])[CH2:12][CH2:13][CH2:14][C:15]1[S:16][CH:17]=[CH:18][CH:19]=1.C(OP(CCCCC1C=CSC=1Br)(=O)OCC)C>>[CH3:9][O:10][C:11](=[O:20])[CH2:12][CH2:13][CH2:14][C:15]1[S:16][C:17]([Br:8])=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 67184N-bromobutanimideHCID 1407664-(2-Thienyl)butanoic acid methyl esterHCID 18680339HCID 18680339, compound

Product 1

HCID 18474982407636-44-6Yield 90%

Procedure

The NBS bromination of 1b according to the procedure outlined for the preparation of 2a gave >90% yield of 2b as a colorless oil. b.p.: 138° C. at 0.15 mmHg. 1H NMR (250 MHz, 25° C., CDCl3): δ6.82 (d, 1H, Ar—H), 6.52 (d, 1H, Ar—H), 3.64 (s, 3H, OCH3), 2.79 (t, 2H, CH2CO2Me), 2.33 (t, 2H, Ar—CH2), 1.93 (tt, 2H, CH2CH2CH2).

Sources & evidence

ORD record
ord-7f1133073b42433986eb87501c6dd032
Source dataset
uspto-grants-2002_07
Patent number
US06414164B1

Reaction notes

Loading…