Hydrochloric Acid → 3-(4-Benzyloxyphenyl)propionic acid

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 3-(4-benzyloxyphenyl)propanoate in ethanol (200 ml) and THF (100 ml) was treated with an aqueous solution of potassium hydroxide (6.7 g, 1.5 N, 101.2 mmol). The mixture was stirred at 60° C. for 1.5 hours, cooled to room temperature, adjusted to pH 3-4 with 1N HCl. The solvent was removed in vacuo to give the title material (12.8 g, 98%) as a white solid.

Provenance & Evidence