L-Tyrosine, N-benzoyl-, ethyl ester → HCID 70122199, compound

HRID 2227895Notes

Reaction equation

HRID 2227895 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[C@H:5]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1)[NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2].[CH2:24]([S:36][CH:37](O)[CH3:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35]>>[CH2:1]([O:3][C:4](=[O:23])[C@H:5]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:38][CH2:37][S:36][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:18][CH:17]=1)[NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 77033L-Tyrosine, N-benzoyl-, ethyl esterHCID 18475006HCID 18475006, compound

Product 1

HCID 70122199HCID 70122199, compoundYield 66.5%

Procedure

N-Benzoyl-L-tyrosine ethyl ester (4.0 g, 12.76 mmol) and dodecanylthioethanol [Patent Application WO 99/15129] (3.15 g, 12.76 mmol) were reacted as described in Example 2 for the preparation of 1-[2-{2-[bis(4-chlorophenyl)ethyl]methylamino}ethoxy]-4-bromo-benzene and gave the title material (4.6 g, 66%) as a white solid.

Sources & evidence

ORD record
ord-784e768c73a4434fbe24afaa73d03200
Source dataset
uspto-grants-2002_07
Patent number
US06414179B1

Reaction notes

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