HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
Reaction Steps
A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin4-one (2.82 g, 0.01 mol), thionyl chloride (40 ml) and DMF (0.28 ml) was stirred and heated to reflux for 1 hour. The mixture was evaporated, the residue was taken up in toluene and evaporated to dryness to give 7-benzyloxy-4-chloro-6-methoxyquinazoline (3.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414148B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-f3251e3b663844b1a2113c359dc2747a |
| Source note | uspto-grants-2002_07 |