Nitric Acid → HCID 135513647, compound

HRID 2227922Notes

Reaction equation

HRID 2227922 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[N:13]=[CH:12][NH:11][C:10]2=[O:19]>O>[CH3:5][O:6][C:7]1[C:8]([N+:1]([O-:4])=[O:2])=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[N:13]=[CH:12][NH:11][C:10]2=[O:19]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 1354950166,7-Dimethoxy-3H-quinazolin-4-one

Product 1

HCID 135513647HCID 135513647, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
120 °C

Procedure

Fuming nitric acid (47 ml) was added to 6,7-dimethoxy-3,4-dihydroquinazolin-4-one (10 g, 48 mmol), in water (40 ml). The reaction mixture was heated at 120° C. for 1 hour, then allowed to cool and diluted with water. The resulting precipitate was collected by filtration, washed with water and dried to give 6,7-dimethoxy-5-nitro-3,4-dihydroquinazolin-4-one (3.9 g, 32%).

Workup

  1. temperatureto cool
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-aa1aed9f4e894b73997813c99099e4bd
Source dataset
uspto-grants-2002_07
Patent number
US06414148B1

Reaction notes

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