HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2227934Generated: November 1, 2026
Pyrrolidine → 4-(Pyrrolidin-1-YL)but-2-YN-1-OL
https://huagongshe.com/reaction/2227934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Butyn-1-ol, 4-chloro- | HCID 202775 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(Pyrrolidin-1-YL)but-2-YN-1-OL | HCID 14278609 | 69% |
Reaction Steps
Pyrrolidine (7.8 ml, 94 mmol) was added dropwise to a solution of 4-chlorobut-2-yn-1-ol (4.74 g, 45 mmol) in toluene (40 ml) and the mixture stirred and heated at 60° C. for 1 hour. The volatiles were removed by evaporation and the residue was purified by chromatography eluting with methylene chloride/methanol (96/4) to give 4-(pyrrolidin-1-yl)but-2-yn-1-ol (4.3 g, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06414148B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-7ea2fb6c9ed144f8b98c707f069fc95f |
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| Source note | uspto-grants-2002_07 |
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