HuagongsheHuagongshe Chemistry Print Report · For research reference only
Gamma-Butyrolactone → 1-(3-Hydroxypropyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Gamma-Butyrolactone | HCID 7302 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Product | 1-(3-Hydroxypropyl)pyrrolidin-2-one | HCID 566744 | 17.5% |
Reaction Steps
A solution of γ-butyrolactone (8.6g, 0.1 mol) and 3-amino-1-propanol (9 g, 0.12 mol) was heated at reflux for 18 hours. The crude product mixture was distilled under reduced pressure to give 1-(3-hydroxypropyl)-2-pyrrolidinone (2.5 g. 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414148B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-d52ae20b358d41e78ca5083e5d8d86f2 |
| Source note | uspto-grants-2002_07 |