methyl 4-[(Z)-3-(imidazol-1-yl)-2-(thiazol-2-yl)-prop-1-enyl]-2-phenyl-benzoate → Methyl 4-[3-(imidazol-1-yl)-2-(thiazol-2-yl)-propyl]-2-phenyl-benzoate

Participants

Reaction Steps

A suspension of methyl 4-[(Z)-3-(imidazol-1-yl)-2-(thiazol-2-yl)-prop-1-enyl]-2-phenyl-benzoate (see this Example, compound a), step B) (1.2 g; 3 mmol) and 10% Pd/C (0.3 g) in MeOH (10 ml) was hydrogenated for 6 hours. After filtration of the catalyst and evaporation to dryness the residue was purified by flash chromatography eluting with CH2Cl2/EtOH (98/2) to give methyl 4-[3-(imidazol-1-yl)-2-(thiazol-2-yl)-propyl]-2-phenyl-benzoate. Yield=25%.

Provenance & Evidence