HCID 54042496, compound → HCID 18474660, compound

HRID 2227997Notes

Reaction equation

HRID 2227997 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH:26][N:27]2[C:31]([CH3:32])=[CH:30][N:29]=[CH:28]2)[CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:11]=2)=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:26][N:27]2[C:31]([CH3:32])=[CH:30][N:29]=[CH:28]2)[CH2:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[C:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 54042496HCID 54042496, compound

Product 1

HCID 18474660HCID 18474660, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of E and Z isomers of methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-prop-2-enyl]-2-phenyl-benzoate (2 g; 4.69 mmol) and 10% Pd/C (0.55 g) in MeOH (25 ml) was hydrogenated for 22 hours. After filtration of the catalyst, the solvent was evaporated to give methyl 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-propyl)-2-phenyl-benzoate as an oil which was used in the next step without further purification.

Workup

  1. filtrationAfter filtration of the catalyst
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-87261d8003ad4813a73556e006c8163c
Source dataset
uspto-grants-2002_07
Patent number
US06414145B1

Reaction notes

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