Sodium Hydroxide → HCID 18474589, compound

Participants

Reaction Steps

Product from step B in solution in methanol (25 ml) was treated at reflux for 2 hours with NaOH 2N (5.8 ml). After evaporation to dryness and neutralisation at pH6 with 6N HCl, the resulting solid was filtered and purified on reverse phase silica eluting with MeOH/(NH4)2CO3 buffer (2 g/l, pH7) 40/60 to give 4-[2-(4-fluorophenyl)-3-(5-methylimidazol-1-yl)-propyl]-2-phenyl-benzoic acid.

Provenance & Evidence