Sodium Hydroxide → HCID 53635251, compound

Participants

Reaction Steps

A solution of methyl 2-(4-fluorophenyl)-4-[2-(thiazol-2-yl)-3-(imidazol-1-yl)prop-1-en-1-yl]benzoate (E and Z isomers) (1.99 g; 5 mmol) in methanol (20 ml) was refluxed with 2N aqueous sodium hydroxide solution (5 ml; 10 mmol) for 2 hours. Methanol was then evaporated and the solution acidified to pH 5.5 with 6N HCl. The resulting precipitate was filtered, washed with water and dried to give 2-(4-fluorophenyl)-4-[2-(thiazol-2-yl)-3-(imidazol-1-yl)prop-1-en-1-yl]benzoic acid as a mixture of E and Z isomers. Yield=80%.

Provenance & Evidence