HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-methyl-5-phenylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Methyl-5-phenylbenzoic acid | HCID 18474599 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Product | Methyl 3-methyl-5-phenylbenzoate | HCID 11379139 | 94% |
Reaction Steps
A solution of 3-methyl-5-phenylbenzoic acid (3.5 g; 16.5 mmol) and concentrated H2SO4 (30 drops) in methanol (25 ml) was heated at reflux overnight. After evaporation to dryness, the residue was extracted with ether. The organic phase was evaporated and purified by flash chromatography eluting with petroleum ether/ethyl acetate (90/10) to give methyl 3-methyl-5-phenylbenzoate as an oil. Yield=94%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06414145B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-48ddedae0c894ffa8b2c2b9042f7762e |
| Source note | uspto-grants-2002_07 |