Azobisisobutyronitrile → Methyl 3-bromomethyl-5-phenylbenzoate

Participants

Reaction Steps

A solution of methyl 3-methyl-5-phenylbenzoate (3.5 g; 15.6 mmol); N-bromosuccinimide (2.78 g; 15.6 mmol), 2,2′-azobis(2′-methylpropionitrile) (0.12 g; 0.72 mmol) and benzoylperoxide (0.12 g; 0.48 mmol) in tetrachloroamethane (120 ml) was heated at reflux for 5 hours. After evaporation to dryness, the residue was purified by flash chromatography eluting with petroleum ether/ethyl acetate (97/3) to give methyl 3-bromomethyl-5-phenylbenzoate as a solid. Yield=80%.

Provenance & Evidence