1,2-Dichloroethane → HCID 59117364, compound

Participants

Reaction Steps

A mixture of 2-[2-(4-fluorophenyl)ethyl]-5-[(E)-2-(4-fluorophenyl)-3-(imidazol-1-yl)prop-1-en-1-yl]benzoic acid (0.3 g; 0.67 mmol), EDC (0.154 g; 0.8 mmol), HOBT (0.108 g; 0.8 mmol), DMAP (0.090 g; 0.74 mmol), L-methionine methyl ester hydrochloride (0.2 g; 1 mmol) and N-Methylmorpholine (110 μl; 1 mmol) in dichloromethane (20 ml) was stirred at room temperature overnight. The organic phase was washed with aqueous sodium bicarbonate, dried and evaporated. The residue was purified by flash chromatography. eluting with a gradient of dichloromethane/ethanol (1-3%) to give methyl (2S)-2-{5-[(E)-2-(4-fluorophenyl)-3-(imidazol-1-yl)prop-1-en-1-yl]-2-(2-(4-fluorophenyl)ethyl)benzamido}-4-methylsulfanylbutyrate as a white solid foam Yield=50%.

Provenance & Evidence