4-(4-Nitrobenzyl)morpholine → 4-(Morpholinomethyl)aniline

Participants

Reaction Steps

In ethanol (300 ml) was dissolved 4—(4-nitrobenzyl)-morpholine (25.8 g), and to the mixture was added dried 10% palladium on carbon (Pd-C) (1.00 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 20 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate) to give 4—(4-aminobenzyl)-morpholine (430 mg) as pale yellow crystals.

Provenance & Evidence