Methyl iodide → HCID 21268026, compound

Participants

Reaction Steps

In DMF (2 ml) was dissolved 7-cyclohexyl-N-[4—(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide (120 mg), and to the mixture was added methyl iodide (45 μl). The mixture was stirred at room temperature for 24 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give 1-[4—(7-cyclohexyl-3,4-dihydro-naphthalene-2-carboxamido) benzyl]-1-methylpiperidinium iodide (Compound 2) (148 mg) as colorless crystals.

Provenance & Evidence