Methyl iodide → HCID 18472580, compound

Participants

Reaction Steps

A solution of 7—(4-methylphenyl)-2-phenyl-N-(4—(piperidinomethyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide (0. 08 g) and methyl iodide (0.05 ml) in dimethylformamide (15 ml) was stirred at room temperature overnight. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol-ethyl acetate to give 1—(N-(7—(4-methylphenyl)-2-phenyl-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-aminobenzyl)-1-methylpiperidinium iodide (Compound 103) (0.057 g) as colorless crystals.

Provenance & Evidence