HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide → 7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide | HCID 18472245 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(4-dimethylaminophenyl)-N-(4-((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide hydrochloride | HCID 18472280 | — |
Reaction Steps
To a solution of 7—(4-dimethylaminophenyl)-N-(4—((1-oxophosphorinan-1-yl)methyl)phenyl)-2.3-dihydro-1-benzoxepine-4-carboxamide (0.1 g) in ethanol was added 4N hydrochloric acid-ethyl acetate (0.2 ml) under ice-cooling. The solvent was evaporated, and the residue was crystallized from ethanol and diethylether to give 7—(4-dimethylaminophenyl)-N-(4—((1-oxophosphorinan-1-yl)methyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide hydrochloride (Compound 155) (0.1 g) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413947B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-cb780e0684884166a0bc2988bdb5b748 |
| Source note | uspto-grants-2002_07 |