HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrobenzyl)phosphorinane-1-oxide → 1-(4-Aminobenzyl)phosphorinane-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrobenzyl)phosphorinane-1-oxide | HCID 18472224 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Aminobenzyl)phosphorinane-1-oxide | HCID 22989986 | 75.6% |
Reaction Steps
A mixture of 1—(4-nitrobenzyl)phosphorinane-1-oxide (2.25 g) and 10% Pd-C (0.2 g) in ethanol (30 ml) was vigorously stirred under hydrogen atmosphere for 24 hours. The catalyst was filtered off, and the filtrate was concentrated recrystallized from ethanol-diethylether to give 1—(4-aminobenzyl)-phosphorinane-1-oxide (1.5 g) as pale yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06413947B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-9381886c69b740258a956f0561851a97 |
| Source note | uspto-grants-2002_07 |