2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 2228326Notes

Reaction equation

HRID 2228326 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>[O-2].[O-2].[Mn+4].CC(C)=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

Participants

4

Reactant 1

HCID 110308742-Amino-5-bromobenzenemethanol

Product 1

HCID 235104752-Amino-5-bromobenzaldehydeYield 71.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To acetone (300 ml)were added (2-amino-5-bromophenyl)methanol (23.32 g) and active manganese dioxide (58.5 g), and the mixture was stirred at room temperature for 17.5 hours and filtered. The solvent was evaporated under reduced pressure to give 2-amino-5-bromobenzaldehyde (16.41 g, 71%).

Workup

  1. filtrationfiltered
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8798c2d24c7849bca72da4dbac9e27e4
Source dataset
uspto-grants-2002_07
Patent number
US06413947B1

Reaction notes

Loading…