5-Amino-2-methoxyphenol → HCID 12016873, compound

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Reaction Steps

1-Bromo-2,3,4-trifluoro-5-[(3-hydroxy-4-methoxyphenyl)amino-sulfonyl]benzene and 1-Bromo-4,5,6-trifluoro-2-[(3-hydroxy-4-methoxyphenyl)amino-sulfonyl]benzne were prepared in a manner similar to that described above, beginning with a mixture of 5-bromo-2,3,4-trifluorophenylsulfonyl chloride (Example B) and2-bromo-3,4,5-trifluorophenylsulfonyl chloride (Example C) and 3-hydroxy4-methoxyaniline. The two isomeric compounds were separated by column chromatography (silica gel; ethyl acetate:hexanes, 1:4). 1H-NMR (CDCl3): δ 7.79 (1H, m), 6.72-6.62 (4H, m), 5.65 (1H, s), 3.85 (3H, s).

Provenance & Evidence