HCID 18469984, compound → HCID 10178875, compound

HRID 2228445Notes

Reaction equation

HRID 2228445 reaction equation
Cl.[NH:2]1[CH2:6][CH2:5][N:4]=[C:3]1[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[CH:20][C:19]=2[F:30])=[O:17])=[CH:10][CH:9]=1.NC1C=CC(CCC(C2C=CC(F)=CC=2)=O)=CC=1.NC1C=CC(CCC(C2C=CC(F)=CC=2F)=O)=CC=1>>[NH:4]1[CH2:5][CH2:6][N:2]=[C:3]1[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)=[CH:20][C:19]=2[F:30])=[O:17])=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 18469984HCID 18469984, compoundHCID 18470000HCID 18470000, compoundHCID 18470023HCID 18470023, compound

Product 1

HCID 10178875HCID 10178875, compound

Procedure

3-[4-(4,5-Dihydro-1H-imidazol-2-ylamino)phenyl]-1-(2-fluoro-4-morpholin-4-ylphenyl)propan-1-one hydrochloride salt, m.p. 168-171° C. Analysis for C22H26CIFN4O2.0.75H2O: Calcd.: C, 56.19; H, 6.21; N, 12.55. Found: C, 59.13; H, 6.00; N, 12.56, was prepared similarly to the procedures described in Example 3, but substituting 3-(4-aminophenyl)-1-(4-fluorophenyl)-propan-1-one in Example 3a with 3-(4-aminophenyl)-1-(2,4-difluorophenyl)-propan 1-one, and proceeding correspondingly.

Workup

  1. customN, 12.56, was prepared similarly to the procedures

Sources & evidence

ORD record
ord-3b21b1bae3e04a43beda5f97c377a30f
Source dataset
uspto-grants-2002_07
Patent number
US06417186B1

Reaction notes

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