Triethylamine → HCID 18470012, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2,2,2-trifluoro-N-{4-[3-oxo-3-(4-piperazin-1-ylphenyl)propyl]-phenyl}acetamide (0.45 g, 1.1 mmol) was treated with methanesulfonyl chloride (0.15 g, 1.32 mmol) and triethylamine (0.28 g, 2.75 mmol) in N,N-dimethyl-formamide (5 mL). The reaction mixture was stirred for 15 minutes at 0° C., diluted with ice water, and extracted with ethyl acetate. The organic extract was washed with water and brine, dried, and concentrated in vacuo to give the title compound as a white solid (0.45 g, 85%).

Provenance & Evidence