tert-butyl N-(4-aminobutyl)carbamate → N-t-Butyloxycarbonyl-N'-(3-[2-Chloro-6-Fluorophenyl]-5-Methylisoxazol-4-oyl)-1,4-Diaminobutane

Participants

Reaction Steps

N-t-butyloxycarbonyl-1,4-diaminobutane (985 mg, 5.23 mmol) and 3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-oyl chloride (1.43 g, 5.23 mmol) were converted to 2.23 g of the title compound by the procedure of Preparation 1 except that the reaction time was about 18 hours. (100%). EA calculated for: C20H25N3O4ClF: C, 56.41; H, 5.92; N, 9.87. Found: C, 56.12; H, 5.75; N, 9.67. MS(FD) m/z 426 (M+).

Provenance & Evidence