HRID2228478

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2736581

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

C11H6Cl2FNO2

HCID13807349

Methyl 7-aminoheptanoate--hydrogen chloride (1/1)

C8H18ClNO2

PRODUCTS

生成物

结构：COC(=O)CCCCCCNC(=O)c1c(-c2c(F)cccc2Cl)noc1C

HCID18470606

未命名化合物

收率 99.5%

PROCEDURE

实验过程

Methyl-7-aminoheptanoate hydrochloride (733 mg, 3.75 mmol) and 3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-oyl chloride (1.03 g, 3.75 mmol) were converted to 1.48 g of the title compound by the procedure of Preparation 10. (100%). EA calculated for: C19H22N2O4ClF: C, 57.51; H, 5.59; N, 7.06. Found: C, 57.78; H, 5.70; N, 6.80. MS(FD) m/z 396.1 (M+).