(Iodomethyl)cyclobutane → 4-Amino-6-cyclobutylmethyloxy-7-methoxy-2-[4-(4-morpholinecarbonyl)-1,4-diazepan-1-yl]quinazoline

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The title compound was prepared from 4-amino-6-hydroxy-7-methoxy-2-[4-(4-morpholinecarbonyl)-1,4-diazepan-1-yl]quinazoline and iodomethyl cyclobutane [Bailey et al J Org Chem, 60, 297-300 (1995)] following a similar procedure to that described in Example 2(b), and was obtained as a solid (14%). Rf 0.40 (0.880 aqueous ammonia:methanol:dichloromethane 1:7:92, v/v). MS m/z 471 (MH)+. Found: C, 59.35; H, 7.12; N, 17.44; C24H34N6O4 0.15CH2Cl2 0.15 H2O, requires C, 59.68; H, 7.18; N, 17.28%.

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