HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanol → 4-Cyano-3-fluoro-5-cyclobutyloxyanisole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanol | HCID 76218 | — |
| Reactant | 2,6-Difluoro-4-methoxybenzonitrile | HCID 2778772 | — |
| Product | 4-Cyano-3-fluoro-5-cyclobutyloxyanisole | HCID 22335444 | 92% |
Reaction Steps
The subtitle compound was prepared from 4-cyano-3,5-difluoroanisole and cyclobutanol following the procedure described in Example 14(a). The crude product was purified on silica gel eluting with dichloromethane:hexane (60:40 v/v) to give the subtitle compound as a white solid (92%). Rf 0.26 (dichloromethane:hexane 1:2, v/v). MS m/z 239 (MNH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417194B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-847e0c537e50439c906ebae4c8afbe67 |
| Source note | uspto-grants-2002_07 |