HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Cyclobutyloxy-4-methoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane | HCID 15538286 | — |
| Reactant | 3-Amino-4-cyano-5-cyclobutyloxyanisole | HCID 18470644 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Cyclobutyloxy-4-methoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}benzonitrile | HCID 17773627 | — |
Reaction Steps
The subtitle compound was prepared from 3-amino-4-cyano-5-cyclobutyloxyanisole and 1-acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane following the procedure described in Example 14(d) (93%). Rf 0.52 (dichloromethane:methanol:0.880 aqueous ammonia, 92:7:1, v/v). MS m/z 456 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417194B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-f8ec0ae2fa4948c3a55cbe60dc752ba8 |
| Source note | uspto-grants-2002_07 |