HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane → 3,4-Dimethoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}-2-(2,2,2-trifluoroethoxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane | HCID 15538286 | — |
| Reactant | 2-Cyano-4,5-dimethoxy-3-(2,2,2-trifluoroethoxy)aniline | HCID 18470652 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3,4-Dimethoxy-6-{1-[4-(morpholinecarbonyl)-1,4-diazepan-1-yl]ethylideneamino}-2-(2,2,2-trifluoroethoxy)benzonitrile | HCID 17773629 | — |
Reaction Steps
The subtitle compound was prepared from 2-cyano-4,5-dimethoxy-3-(2,2,2-trifluoroethoxy)aniline and 1-acetyl-4-(4-morpholinecarbonyl)-1,4-diazepane following the procedure described in Example 10(g) (73%). Rf 0.16 (dichloromethane:methanol 95:5, v/v). MS m/z 514 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417194B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-19d363fb68e848c7b21a8344923a07aa |
| Source note | uspto-grants-2002_07 |