HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 6-Cyclobutyloxy-3,4-dimethoxy-[1-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)ethylideneamino]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-Cyano-3-cyclobutyloxy-4,5-dimethoxyaniline | HCID 18470654 | — |
| Reactant | 2-Acetyl-5-methanesulfonamido-1,2,3,4-tetrahydroisoquinoline | HCID 18768488 | — |
| Product | 6-Cyclobutyloxy-3,4-dimethoxy-[1-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)ethylideneamino]benzonitrile | HCID 18470643 | 85% |
Reaction Steps
The subtitle compound was prepared from 2-cyano-3-cyclobutyloxy-4,5-dimethoxyaniline and 2-acetyl-5-methanesulfonamido-1,2,3,4-tetrahydroisoquinoline following the procedure described in Example 10(g). Trituration with diethyl ether afforded the subtitle compound as a colourless solid (85%). Rf 0.14 (ethyl acetate:hexane 1:1, v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417194B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-98f26ac9b0194acd9e943f4641fcb4dd |
| Source note | uspto-grants-2002_07 |