1-Fluoro-2-nitrobenzene → HCID 68839198, compound

HRID 222855Notes

Reaction equation

HRID 222855 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH:11]1([C:17]2[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C([O-])(C)(C)C.[K+]>CS(C)=O>[CH:11]1([C:17]2[CH:18]=[CH:19][C:20]([NH:21][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[N+:8]([O-:10])=[O:9])=[CH:22][CH:23]=2)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

5

Reactant 3

HCID 738951-Fluoro-2-nitrobenzeneHCID 807644-CyclohexylbenzenamineHCID 23665647Potassium tert-butoxide

Product 1

HCID 68839198HCID 68839198, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The product (280 mg) is obtained according to the method of stage 1 of Example 4, by using 400 μL of 2-fluoro-nitrobenzene and 1 g of 4-cyclohexylaniline in the presence of 683 mg of potassium tert-butanolate in 4 mL of DMSO.

Sources & evidence

ORD record
ord-c6cbe13f1c35488da68276c523969d26
Source dataset
uspto-grants-2012_06
Patent number
US08207373B2

Reaction notes

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