4-tert-Butylbenzoyl chloride → Methyl 4-amino-3-[(4-tert-butylbenzoyl)amino]benzoate

HRID 2228575Notes

Reaction equation

HRID 2228575 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([NH2:12])[C:8]([NH2:11])=[CH:9][CH:10]=1)=[O:4].[C:13]([C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1)([CH3:16])([CH3:15])[CH3:14]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([NH:12][C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:17]([C:13]([CH3:15])([CH3:14])[CH3:16])=[CH:18][CH:19]=2)[C:8]([NH2:11])=[CH:9][CH:10]=1)=[O:4]

Participants

3

Reactant 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 1355243,5-Diamino-2-methylbenzoic acid

Product 1

HCID 10687588Methyl 4-amino-3-[(4-tert-butylbenzoyl)amino]benzoate

Procedure

Using a procedure similar to Example 1B except starting with 4-methoxycarbonyl-1,2-benzenediamine and 4-t-butylbenzoyl chloride, the title compound was obtained as a solid (10.8 g, 65%); MS(FD): 326.2.

Sources & evidence

ORD record
ord-99a26e4f8d0f468bacab211822cfbb53
Source dataset
uspto-grants-2002_07
Patent number
US06417200B1

Reaction notes

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