反应详情

温度

100 °C

Ethyl 6-chloronicotinate (5.0 g) and morpholine (10 ml) were mixed and then heated to 100° C. In less than 5 minutes at this temperature, a thick paste formed. Acetonitrile (15 ml) was added and heating was continued overnight at 90° C. The mixture was cooled, diluted with water and extracted with ethyl acetate. The organic layer was dried and concentrated in vacuo to give ethyl 6-morpholin-4-ylpyridine-3-carboxylate as a white solid. NMR (300 MHz, CDCl3: 8.80 (s, 1H), 8.05 (d, 1H), 6.60 (d, 1H), 4.35 (q, 2H), 3.80 (m, 4H), 3.65 (m, 4H), 1.35 (t, 3H).

1. waitIn less than 5 minutes at this temperature
2. customa thick paste formed
3. temperatureheating
4. temperatureThe mixture was cooled
5. extractionextracted with ethyl acetate
6. customThe organic layer was dried
7. concentrationconcentrated in vacuo