Morpholine → Ethyl 4-(4-cyanophenyl)-2-[(2-{[5-(morpholin-4-ylcarbonyl) (2-pyridyl)]amino}ethyl)amino]pyrimidine-5-carboxylate

HRID 2228601Notes

Reaction equation

HRID 2228601 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]([C:10]1[CH:11]=[CH:12][C:13]([NH:16][CH2:17][CH2:18][NH:19][C:20]2[N:25]=[C:24]([C:26]3[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][CH:27]=3)[C:23]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:22][N:21]=2)=[N:14][CH:15]=1)=[O:9]>ClCCl>[C:32]([C:29]1[CH:30]=[CH:31][C:26]([C:24]2[C:23]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:22][N:21]=[C:20]([NH:19][CH2:18][CH2:17][NH:16][C:13]3[CH:12]=[CH:11][C:10]([C:8]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:9])=[CH:15][N:14]=3)[N:25]=2)=[CH:27][CH:28]=1)#[N:33]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 22142924HCID 22142924, compound2×

Product 1

HCID 22142703Ethyl 4-(4-cyanophenyl)-2-[(2-{[5-(morpholin-4-ylcarbonyl) (2-pyridyl)]amino}ethyl)amino]pyrimidine-5-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The solution of ethyl 2-({2-[(5-(chlorocarbonyl)(2-pyridyl))amino]ethyl}amino)-4-(4-cyanophenyl)pyrimidine-5-carboxylate in dichloromethane prepared in Step 1 of Example 71 (1.0 ml) was treated at room temperature with a solution of morpholine (150 μL) in dichloromethane (1 ml). After 1 hour the solvent was removed in vacuo to give the title compound.

Workup

  1. customAfter 1 hour the solvent was removed in vacuo

Sources & evidence

ORD record
ord-592dfce8cb1140af8e410f9ca8ab82a6
Source dataset
uspto-grants-2002_07
Patent number
US06417185B1

Reaction notes

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