Sodium Bicarbonate → HCID 18470722, compound

Participants

Reaction Conditions

Reaction Steps

3-Acetyl-4-methoxymethyl-2,5-di(4-pyridyl)-1H-pyrrole (0.36 g, 1.17 mmol) was dissolved in 10% aqueous HCl solution (14 mL). The mixture was heated at 70° C. for 15 hours. After cooling, the mixture was neutralized with saturated aqueous sodium bicarbonate solution. Insolubles were filtered off, and the filtrate was extracted with ethyl acetate-EtOH (5:1, 200 mL×2). The combined organic layers were washed with brine (50 mL), dried over MgSO4, and concentrated ill vaciio. The crude product was recrystallized from ethyl acetate to provide the title product (150 mg, 44% yield) as a solid.

Provenance & Evidence