HCID 12051828, compound → HCID 12051829, compound

Participants

Reaction Steps

To a stirred suspension of lithium aluminum hydride (LAH) (88 mg, 2.31 mmol) was added 3-ethoxycarbonyl-1-methoxymethyl-4-methyl-2,5-di(4-pyridyl)-1H-pyrrole (270 mg, 0.77 mmol) at 0° C. under nitrogen. After stirring for 2 hours, the reaction mixture was allowed to warm to room temperature and stirred for 3 days. Saturated aqueous ammonium chloride solution (50 mL) was added to the mixture, and the whole was extracted with ethyl acetate (70 mL×2). Combined organic layers were washed. with brine (50 mL), dried over MgSO4, and concentrated il vacuo to afford the subtitle compound (180 mg, 5.8% yield) as a solid.

Provenance & Evidence