Sodium Bicarbonate → HCID 12051830, compound

Participants

Reaction Steps

3-Hydroxymethyl-1-methoxymethyl-4-methyl-2,5-di(4-pyridyl)-1H-pyrrole (150 mg, 0.49 mmol) was dissolved in 10% aqueous HCl solution (20 mL) and the mixture was stirred for 1 day at room temperature then heated at reflux temperature for 1 hour. After cooling, the mixture was neutralized with saturated aqueous sodium bicarbonate solution. Volatiles were removed by evaporation, and the residue was suspended in EtOH. After removal of insolubles by filtration, the filtrate was concentrated in vacto. The crude product was purified by flash chromatography eluting with CH2Cl2—EtOH (5:1), followed by recrystallization from EtOH to give the title compound (30 mg, 23% yield) as a solid.

Provenance & Evidence