4-Fluorophenylboronic acid → HCID 18470731, compound

HRID 2228618Notes

Reaction equation

HRID 2228618 reaction equation
[C:1]([C:4]1[C:8]([CH3:9])=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[NH:6][C:5]=1Br)(=[O:3])[CH3:2].[F:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[C:1]([C:4]1[C:8]([CH3:9])=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[NH:6][C:5]=1[C:21]1[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 18470740HCID 18470740, compound

Product 1

HCID 18470731HCID 18470731, compound

Procedure

The title compound was prepared from 3-acetyl-2-bromo-4-methyl-5-(4-pyridyl)-1H-pyrrole according to the procedure of Example 46 using 4-fluorophenylboronic acid instead of 4-pyridylboronic acid in step 3.

Sources & evidence

ORD record
ord-73300104a608411692ce597cbef4a01f
Source dataset
uspto-grants-2002_07
Patent number
US06417202B1

Reaction notes

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