1-Fluoro-2-nitrobenzene → HCID 68839617, compound

HRID 222862Notes

Reaction equation

HRID 222862 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[O:11]([C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([O-])(C)(C)C.[K+]>CS(C)=O>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:21][C:20]1[CH:22]=[CH:23][CH:24]=[C:18]([O:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:19]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 738951-Fluoro-2-nitrobenzeneHCID 771353-PhenoxyanilineHCID 23665647Potassium tert-butoxide

Product 1

HCID 68839617HCID 68839617, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The product (2.08 g) is obtained according to the method of stage 1 of Example 4, by using 1.23 mL of 2-fluoronitrobenzene and 3.3 g of 3-phenoxyaniline in the presence of 2.13 g of potassium tert-butanolate in 10 mL of DMSO.

Sources & evidence

ORD record
ord-d5b224570a7a457a96a15e049bdef6c6
Source dataset
uspto-grants-2012_06
Patent number
US08207373B2

Reaction notes

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