Methanol → HCID 18470744, compound

Participants

Reaction Steps

To a stirred solution of 3-acetyl-4-methyl-2-(4-methylthiophenyl)-5-(4-pyridyl)-1H-pyrrole (0.24 g, 0.74 mmol) in methanol (8 mL) was added a solution of NaIO4 (0.6 g) in water (16 mL) at room temperature. After stirring for 15 hours, the precipitates were collected by filtration. The filtrate was extracted with CH2Cl2—EtOH (10:1, 50 mL×2), dried over MgSO4, and concentrated ini vacuo. The solids were purified by flash chromatography eluting with CH2Cl2—EtOH (10:1) to provide the title compound (0.24 g, quantitative yield).

Provenance & Evidence