Sodium Bicarbonate → HCID 18470730, compound

Participants

Reaction Steps

A mixture of methyl 5-bromo-4-methyl-2-phenylpyrrole-3-carboxylate (82 mg, 0.278 mmol), 4-pyridylboronic acid (68 mg, 0.556 mmol), PdCl2(PPh3)2 (20 mg, 0.0278 mmol), and saturated aqueous NaHCO3 (0.3 mL) in dimethoxyethane (1.5 mL) was refluxed for 16 hours. The mixture was extracted with CH2Cl2 (10 mL×3), the combined organic layer dried over Na2SO4, and concentrated ini vacito. The residue was purified by PTLC (1 mm) with acetone-hexane (1:2) to afford the title compound (37 mg, 46% yield).

Provenance & Evidence