Potassium Carbonate → HCID 15453519, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 26 g of meta-chloroperbenzoic acid (at 55%, 82.9 mmol) in 220 ml of dichloromethane is stirred for one hour and then transferred into a separating funnel. The aqueous phase is separated out and the organic phase is placed in a round-bottomed flask and cooled to 0° C. 18 9 of 2-[2-(2-acetyl-5-fluoro-phenoxy)ethyl]isoindole-1,3-dione (5) (55 mmol) are added portionwise and the mixture is stirred at room temperature for 16 hours. 6.9 g of sodium bicarbonate (82 mmol) are then introduced portionwise and the mixture is stirred for one hour. The mixture is then concentrated under vacuum and 200 ml of methanol are added, followed by addition of 15.2 g of potassium carbonate (110 mmol). The mixture is stirred for 4 hours at room temperature and the solvent is then evaporated off, replaced with 200 ml of dichloromethane and the mixture is washed with water and with saturated aqueous sodium chloride solution. The aqueous phase is dried over sodium sulfate and filtered, and the solvent is evaporated off. The product is crystallized from dichloromethane. 14 g of the title product are obtained in the form of a white solid.

Provenance & Evidence