Isopropyl iodide → HCID 15453525, compound

Participants

Reaction Conditions

Reaction Steps

7.71 g of potassium carbonate (56 mmol) and 7 ml of 2-iodopropane (70 mmol) are added to a solution of 14 g of 2-[2-(5-fluoro-2-hydroxyphenoxy)ethyl]isoindole-1,3-dione (6) (47 mmol) in 250 ml of acetonitrile. The mixture is stirred for 16 hours at 80° C. and the solvent is then evaporated off under reduced pressure and the residue is taken up in diethyl ether. The organic phase is washed with normal aqueous sodium hydroxide solution and then with saturated aqueous sodium chloride solution. It is dried over magnesium sulfate and filtered, and the solvent is evaporated off under vacuum. The title product is isolated by chromatography on a column of silica (eluent: 82/18 cyclohexane/ethyl acetate). 12.2 g of a white solid are isolated.

Provenance & Evidence