HCID 70116357, compound → HCID 12266608, compound

HRID 2228662Notes

Reaction equation

HRID 2228662 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([CH3:10])=[CH:5][C:4]=1/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14].[H][H]>C(O)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][C:6]([CH3:10])=[CH:5][C:4]=1[CH2:11][CH2:12][C:13]([OH:15])=[O:14]

Participants

5

Reactant 2

HCID 70116357HCID 70116357, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12266608HCID 12266608, compoundYield 91.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

In acetic acid (80 mL) were suspended (E)-3-(2-methoxy-3,5-dimethylphenyl)propenoic acid (9.60 g, 46.5 mmol) and 10% palladium-on-carbon (hydrous) (0.60 g) and the suspension was stirred in a hydrogen atmosphere at 60° C. for 14 hours. The catalyst was then filtered off and the filtrate was concentrated under reduced pressure. The residue was crystallized from ethanol to provide 8.90 g of the title compound. Yield 91%.

Workup

  1. filtrationThe catalyst was then filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-295a3e8d44f04dd7b9845044a94e8cfb
Source dataset
uspto-grants-2002_07
Patent number
US06417213B2

Reaction notes

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