2,2-Diphenylethyl iodide → [[2-(2,2-Diphenylethyl)thio-4H-[1]benzopyrano[4,3-d]thiazol-6-yl]oxy]acetic acid

HRID 2228682Notes

Reaction equation

HRID 2228682 reaction equation
[SH:1][C:2]1[S:3][C:4]2[CH2:10][O:9][C:8]3[C:11]([O:15][CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:13]=[CH:14][C:7]=3[C:5]=2[N:6]=1.[C:22]1([CH:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:29]I)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([CH:28]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:29][S:1][C:2]2[S:3][C:4]3[CH2:10][O:9][C:8]4[C:11]([O:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:13]=[CH:14][C:7]=4[C:5]=3[N:6]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 184709932,2-Diphenylethyl iodideHCID 178472956HCID 178472956, compound

Product 1

HCID 70119813[[2-(2,2-Diphenylethyl)thio-4H-[1]benzopyrano[4,3-d]thiazol-6-yl]oxy]acetic acidYield 41%

Procedure

Using ethyl [(2-mercapto-4H-[1]benzopyrano[4,3-d]thiazol-6-yl)oxy]acetate and 2,2-diphenylethyl iodide, the procedure of Example 1 was otherwise repeated to synthesize the title compound. Yield 41%.

Sources & evidence

ORD record
ord-d88ecb222b4a4fcd858978ab14ffcd9b
Source dataset
uspto-grants-2002_07
Patent number
US06417213B2

Reaction notes

Loading…