1,1'-Biphenyl, 4-(bromomethyl)- → [[2-(4-Phenylbenzylthio)-4,5-dihydronaphtho[1,2-d]thiazol-6-yl]oxy]acetic acid

HRID 2228684Notes

Reaction equation

HRID 2228684 reaction equation
[SH:1][C:2]1[S:3][C:4]2[CH2:14][CH2:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=3[O:15][CH2:16][C:17]([O:19]CC)=[O:18])[C:5]=2[N:6]=1.[C:22]1([C:28]2[CH:35]=[CH:34][C:31]([CH2:32]Br)=[CH:30][CH:29]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([C:28]2[CH:29]=[CH:30][C:31]([CH2:32][S:1][C:2]3[S:3][C:4]4[CH2:14][CH2:13][C:12]5[C:7](=[CH:8][CH:9]=[CH:10][C:11]=5[O:15][CH2:16][C:17]([OH:19])=[O:18])[C:5]=4[N:6]=3)=[CH:34][CH:35]=2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 2577161,1'-Biphenyl, 4-(bromomethyl)-HCID 178472952Ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy)acetate

Product 1

HCID 70116980[[2-(4-Phenylbenzylthio)-4,5-dihydronaphtho[1,2-d]thiazol-6-yl]oxy]acetic acidYield 68%

Procedure

Using ethyl [[2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetate and 4-phenylbenzyl bromide, the procedure of Example 1 was otherwise repeated to synthesize the title compound. Yield 68%.

Sources & evidence

ORD record
ord-9e3f8b57fb9c448eb610302e64123f92
Source dataset
uspto-grants-2002_07
Patent number
US06417213B2

Reaction notes

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